The association of lean mass, fat mass and bone mineral density in Vietnamese men and women

Nguyen Thi Thanh Huong1,2, Nguyen Van Hung2, Pham Thanh Tung2, Bui Phuong Linh2, Vu Thi Thanh Thuy3, Nguyen Van Tuan4

1: Physiology Department, Hanoi Medical University

2: Dinh Tien Hoang Institute of Medicine

3: Hanoi Osteoporosis Association

4: Garvan Institute of Medical Research


The research was presented at Hanoi Osteoporosis Association Conference 2014, HCM Osteoporosis Association Conference 2014, and Vietnam Association of Physiology Conference 2014 as poster presentation.


Background: Body weight is an important determinant of bone mineral density (BMD) and osteoporosis. However, body weight is consisted of two main components: lean mass (LM) and fat mass (FM), and the contribution of each component during life span in women and men is not yet well defined.

Objective: To determine how LM and FM affect BMD of Vietnamese women and men at different ages and which body part of lean and fat is more important to predict BMD.

Method: This was designed as the cross-sectional study with 2202 women (1149 premenopausal aged 41.77 ± 8.76 and 1053 postmenopausal aged 61.92 ± 8.18) and 437 men (200 men aged

Result: In women regardless of their age, both LM and FM were independent predictors for BMD at femoral neck and lumbar spine, while only LM showed significantly effect on whole body BMD. The impact of LM was about 3 times stronger than that of FM in premenopausal women, whereas, this was 2 times among postmenopausal counterparts. In men at all age, LM, not FM was the predictor of BMD at all sites.

In Bayesian model average and bootstrap analysis, the best model for BMD prediction in men aged

Conclusion: ASM and age influenced on BMD at all sites in men aged

Keyword: Body composition, Appendicular skeletal muscle, Appendicular fat mass, Lean mass, Fat mass, Bone mineral density, Vietnam